Endocrine Abstracts

Introduction: Current treatment guidelines for patients with insufficiency of the hypothalamic pituitary adrenal (HPA) axis recommend weight adjusted glucocorticoid supplementation doses to minimize risk of negative side effects (e.g. osteoporosis etc).However, little is known on a potential dose-dependent effect of glucocorticoid supplementation on overall mortality in patients with pituitary disease. Non-functioning pituitary adenoma (NFPA) is one of t...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) is a well-known complication of amiodarone therapy. Type 1 AIT is caused by excessive iodine-induced thyroid hormone synthesis in abnormal thyroid glands and treated with thionamides; type 2 AIT is a drug induced destructive thyroiditis that responds to glucocorticoids. Mixed forms of AIT need a combined treatment of thionamides and glucocorticoids. In refractory cases of AIT plasmapheresis before total thyroidectomy is an ...